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Cost was also a notable barrier (12.8% of patients discontinued due to affordability)

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Some previous studies in mammals have shown that gene expression or enzyme activities associated with peroxisomal -oxidation can be enhanced as an adaptation to the inhibition of mitochondrial -oxidation ( Reference Degrace, Demizieux and Du 56 , Reference Tsoko, Beauseigneur and Gresti 59 Reference Wicks, Vandanmagsar and Haynie 62 )